منابع مشابه
Chitosan for Gene Delivery and Orthopedic Tissue
Gene therapy involves the introduction of foreign genetic material into cells in order exert a therapeutic effect. The application of gene therapy to the field of orthopaedic tissue engineering is extremely promising as the controlled release of therapeutic proteins such as bone morphogenetic proteins have been shown to stimulate bone repair. However, there are a number of drawbacks associated ...
متن کاملChitosan nanoparticles for oral drug and gene delivery
Chitosan is a widely available, mucoadhesive polymer that is able to increase cellular permeability and improve the bioavailability of orally administered protein drugs. It can also be readily formed into nanoparticles able to entrap drugs or condense plasmid DNA. Studies on the formulation and oral delivery of such chitosan nanoparticles have demonstrated their efficacy in enhancing drug uptak...
متن کاملChitosan for gene delivery and orthopedic tissue engineering applications.
Gene therapy involves the introduction of foreign genetic material into cells in order exert a therapeutic effect. The application of gene therapy to the field of orthopaedic tissue engineering is extremely promising as the controlled release of therapeutic proteins such as bone morphogenetic proteins have been shown to stimulate bone repair. However, there are a number of drawbacks associated ...
متن کاملApplication of Ferriferous Oxide Modified by Chitosan in Gene Delivery
New approaches to improve the traditional gene carriers are still required. Here we explore Fe(3)O(4) modified with degradable polymers that enhances gene delivery and target delivery using permanent magnetic field. Two magnetic Fe(3)O(4) nanoparticles coated with chitosan (CTS) and polyethylene glycol (PEG) were synthesized by means of controlled chemical coprecipitation. Plasmid pEGFP was enc...
متن کاملChitosan-based Drug Delivery Systems
The most important characteristics of chitosans, which make them useful as delivery vectors for drugs and therapeutic proteins, are their excellent mucoadhesive and absorption enhancing properties [1-3]. The mucoadhesion is due to the electrostatic interaction between the positive charge on the chitosan polymer and the negatively charged sialic acid residues on the mucosal surface [4]. Because ...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2007
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.22.131